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Brand Name : Palbace
Composition : Palbociclib
Strength : 100 mg
Form : Capsules
Packing : Pack of 21 Capsules

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Description

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WHAT IS PALBOCICLIB?

Palbociclib is used in men and women to treat certain types of advanced breast cancer that has spread to other parts of the body.

In postmenopausal women, palbociclib is given in combination with a hormonal medicine called letrozole(Femara). In others, palbociclib is given together with fulvestrant (Faslodex).

Palbociclib may also be used for purposes not listed in this medication guide.

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Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

BEFORE TAKING THIS MEDICINE

You should not use palbociclib if you are allergic to it.

To make sure palbociclib is safe for you, tell your doctor if you have:

Do not use palbociclib if you are pregnant. It could harm the unborn baby. Use effective birth controlto prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose.

You may need to have a negative pregnancy test before starting this treatment.

It is not known whether palbociclib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

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HOW SHOULD I TAKE PALBOCICLIB?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Palbociclib is given in a 28-day treatment cycle, and you may only need to take the medicine during the first 3 weeks of each cycle. Your doctor will determine how long to treat you with palbociclib.

Take with food.

Take the medicine at the same time each day.

Do not crush, chew, break, or open a palbociclib capsule. Swallow it whole.

If you vomit after taking the medicine, wait until the next day to take your next dose.

Do not use a broken or damaged pill.

Palbociclib can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.

Store at room temperature away from moisture and heat.

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WHAT HAPPENS IF I MISS A DOSE?

Skip the missed dose and do not take the medicine again until your next scheduled dose. Do not take extra medicine to make up the missed dose.

WHAT SHOULD I AVOID WHILE TAKING PALBOCICLIB?

Grape fruit and grape fruit  may interact with palbociclib and lead to unwanted side effects. Avoid the use of grapefruit products while taking palbociclib.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

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PALBOCICLIB SIDE EFFECTS

Get emergency medical help if you have signs of an allergic reaction: Hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • low white blood cell counts–Fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
  • low red blood cells (anemia)–pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • signs of a blood clot in the lung–chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • Nausea, Vomiting,Diarrhea , loss of appetite;
  • mouth sores, decreased sense of taste;
  • weakness, feeling tired;
  • numbness, tingling, or burning pain in your arms, legs, hands or feet;
  • abnormal liver function tests;
  • cold symptoms  such as stuffy nose, sneezing, sore throat;
  • nosebleed; or
  • Dry Skin, temporary Hair loss

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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PALBOCICLIB DOSING INFORMATION

Usual Adult Dose for Breast Cancer:

28-day cycle: 125 mg orally once a day for 21 consecutive days followed by 7 days off treatment

Comments: Take with food in combination with letrozole 2.5 mg orally once a day throughout the 28-day cycle.

Use: In combination with letrozole for the treatment of postmenopausal women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy

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WHAT OTHER DRUGS WILL AFFECT PALBOCICLIB?

Other drugs may interact with palbociclib, including prescription and over-the-counter medicines,Vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Palbociclib is an oral chemotherapy used to treat advanced breast cancer. This drug is used as part of a combination therapy. That means it is taken with other drugs. Palbociclib is generally taken in combination with letrozole

Palbace (Palbociclip 125mg) ) is a product of Pfizer and is known as IBRANCE in other parts of the world

The drug was reviewed and approved under the food and drug administration  (FDA) accelerated Priority reviewand breakthrough therapydesignation programs on February of 2015

The drug was approved for use in the European Union in November 2016 as a treatment for hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative locally advanced or metastatic breast cancer

Palbace comes in capsule form in 125 mg dose. 1 pack has 21 capsules.

We Ship in – USA, UK, China, Canada, Russia, Australia, UAE, Singapore, Philippines, Bulgaria, Hungary, Italy, Kenya, Nigeria, Saudi Arabia, Taiwan, Zimbabwe, Malaysia, Spain, Hong Kong and other countries.

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Note:

The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
Remember, keep this and all other medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Palbace 125 Mg Capsule (Palbociclib)

What Is The Generic Name For Palbace 125 Mg Capsule:

Palbociclib is the generic version for Palbace 125 mg Capsule

Which USA Brand is Equivalent To Palbace 125 Mg Capsule (Palbociclib):

Ibrance

About Palbace 125 Mg Capsule (Palbociclib)

Palbace 125 mg Capsule contains an active ingredient, Palbociclib, which is used in the treatment of of breast cancer. This is also used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) which have spread to other organs. This is given together with hormonal anticancer therapies. Breast cancer is type of cancer which develops from breast tissue. Symptoms of breast cancer comprise lump in the breast, dimpling of the skin, a change in breast shape, & fluid coming from the nipple, an inverted nipple, or a red/ scaly patch of skin. This medicine is available at all the leading pharmacy, drugstores, and medical supply stores & must be taken by doctor’s prescription only.

Manufacturer:

Pfizer Ltd. is one of the leading pharmaceutical companies which manufacture Palbace 125 mg Capsule. It can be purchased from our online pharmacy.

Strength:

Palbace 125 mg Capsule contains an active ingredient, Palbociclib, which is available in other substitutes also at all the leading online pharmacy, drugstores, and medical supply stores.

What Are The Uses Of The Palbace 125 Mg Capsule (Palbociclib):

Palbace 125 mg Capsule is used in the treatment in following conditions:

Breast Cancer

How Palbace 125 Mg Capsule (Palbociclib) Works:

Palbace 125 mg Capsule has an active ingredient; Palbociclib is an anticancer medication which works by interfering with a kinase, a type of protein in the body that helps control cell division. This stops cancer cells from dividing & growing.

Before You Use Palbace 125 Mg Capsule (Palbociclib):

Make sure that:

  • You are not allergic to Palbociclib
  • You are not having any serious Disease
  • Your doctor must be informed about your health history like your pre- existing disease, surgeries & Medications, Supplements, Food Habits, lifestyle, etc.

What Should You Avoid While Taking Palbace 125 Mg Capsule (Palbociclib):

  • You should avoid taking alcohol
  • You should avoid driving
  • You should avoid taking Medicines without prescriptions

When Not To Use Palbace 125 Mg Capsule (Palbociclib):

You should not take Palbace 125 mg Capsule if you:

  • Have ever noticed any Allergy/Hypersensitivity
  • Have you have liver problems
  • Have infections
  • Have Neutropenia
  • Have Lung disorder
  • Have Kidney disease
  • Are Pregnant/Conceiving/Breastfeeding

Tell Your Doctor If You:

  • Have Allergy to the Capsule
  • Are taking Alcohol or Other Drugs
  • Have Liver/ Kidney disease
  • Are Pregnant or Trying to Conceive
  • Are Breastfeeding

Dosage:

Palbace 125 mg Capsule contains an active ingredient, Palbociclib, which is used in the treatment of breast cancer. This medicine is available in different strengths and substitutes & must be purchased or given on doctor’s prescription only. You should consult your doctor for dosage and time because age and severity of the disease differ from person to person and it can only be judged by your doctor.

Adults are advised to take Palbace 125 mg Capsule at a fixed time with food as instructed by your Doctor. You must take Palbace 125 mg Capsule regularly on time for better results.

How Much Of The Palbace 125 Mg Capsule (Palbociclib) to Be Used:

As Palbace 125 mg Capsule is available in various strengths and substitutes, Patients are always advised to follow their doctor’s prescriptions and instructions to take Palbace 125 mg Capsule. Do not take the Capsule on your own & for longer time than recommended by doctor.

How To Take The Palbace 125 Mg Capsule (Palbociclib):

Take Palbace 125 mg Capsule in the dose and duration as advised by your doctor. Swallow the Capsule as a whole. Do not chew, crush or break the Capsule. Palbace 125 mg Capsule is to be taken with food, but it is better to take it at a fixed time.

For How Long Should You Continue Using Palbace 125 Mg Capsule (Palbociclib):

You are always advised to take Palbace 125 mg Capsule as prescribed. Do not start/stop using this medicine yourself. Follow all the instructions given by your doctor. Do not take the Capsule in larger or smaller amount or for longer period than suggested by your doctor.

Overdose:

Patient must seek emergency medical attention and/or contact doctor immediately in case of any overdose symptoms. Symptoms like dizziness, tremor, confusion & sweating after taking the dose should be reported immediately. Emergency medical treatment will be initiated by your doctor if they are suspecting overdose symptoms.

Missed Dose:

The missed dosage of the drug must be taken by you as soon as possible. It is appropriate to skip the missed dosage of the drug if it is already time for your next scheduled dosage. You must not take double dosage of the drug to make up for the missed dosage.

What Are The Side Effects Of The Palbace 125 Mg Capsule (Palbociclib):

 

  • Fatigue
  • Hair loss
  • Rash
  • Vomiting
  • Diarrhea
  • Nausea
  • Decreased appetite
  • Infection
  • Hair loss or thinning of the hair
  • Lack or loss of strength
  • Decrease in white blood cells and platelets
  • Anemia
  • Chills and fever

What Are The Common Drug Interactions:

Few medicines have been reported to interact with Palbace 125 mg Capsule. This interaction may produce some unwanted or adverse effects and/or cause your drug not to work properly. You must always discuss with your doctor if you are taking other medication/ Supplements so that well planned medication can be given. It interacts with the following medicines:

  • Phenobarbital
  • Live attenuated vaccines and related products
  • Fentanyl
  • Adalimumab
  • Carbamazepine
  • Clarithromycin

It can also interact with following disease condition:

  • Allergy
  • Infections
  • Liver disorder
  • Lung disorder
  • Kidney disorder

Grapefruit may significantly increase the blood levels of this medicine, so this may cause severe side effects such as nausea, diarrhea, loss of appetite, vomiting, mouth sores, hair loss, weakness, pain, numbness, etc. Hence, consumption of grapefruit is not recommended during treatment with this medicine.

Warning And Precaution:

Palbace 125 mg Capsule can worsen the conditions like:

  • Allergy
  • Liver/kidney disease
  • You must perform blood count, heart/kidney/liver function tests before therapy
  • You should not drive or operate machinery while taking this medicine as it may cause nausea and vomiting
  • Always consult with your doctor immediately to get best possible treatment when you are suffering from any of the above mentioned conditions.

Things To Remember:

  • Keep the Palbace 125 mg Capsule out of reach and sight of the children
  • This medicine is strictly not prescribed for use in children and adolescents
  • You must always read the information precisely written on the leaflet/ insert of the medicine
  • Always consult your physician if you have any doubt in case of the dosage, time & strength of the medicine.

Indications:

Palbace 125 mg Capsule should be taken for cancer treatment. Do not take this medicine for longer period than suggested by the Doctor.

Storage:

Store the Palbace 125 mg Capsule at room temperature in dark and dry place. Make sure the Capsules are intact and not damaged or broken while purchasing or storing.

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