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Clonazepam (Klonopin) is a prescription drug used to treat panic attacks, certain types of seizures, and the short-term relief of the symptoms of anxiety.

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Description

Klonopin (Clonazepam)

Commercial Name: Klonopin, Rivotril
Principal Ingredient: Clonazepam
Utilization: Anti-Anxiety
Available Dosage: 0,5 mg, 1 mg, 2 mg

Klonopin (Clonazepam) Uses

Clonazepam is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Clonazepam works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

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How to use Klonopin

Read the Medication Guide provided by your pharmacist before you start taking clonazepam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as seizures, mental/mood changes, shaking, stomach/muscle cramps). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used clonazepam for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using clonazepam. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures.

Tell your doctor if your condition persists or worsens.

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How to use klonopin (Clonazepam)

Read the Medication Guide provided by your pharmacist before you start taking clonazepam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as seizures, mental/mood changes, shaking, stomach/muscle cramps). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used clonazepam for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using clonazepam. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures.

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klonopin (Clonazepam) Side Effects

Drowsiness, dizziness, tiredness, loss of coordination, or increased saliva production may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A small number of people who take anticonvulsants for any condition (such as seizuresbipolar disorder, pain) may experience depressionsuicidal thoughts/attempts, or other mental/mood problems. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior, including: confusion, memory problems, signs of depressionsuicidal thoughts/attempts, thoughts about harming yourself.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rashitching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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klonopin (Clonazepam) Precautions

Before taking clonazepam, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepamlorazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain type of eye problem (narrow angle glaucoma), a certain blood disorder (porphyria), liver diseasekidney diseaselung/breathing problems, mental/mood problems (such as depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol).

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

For children, the long-term effects on physical and mental/behavioral development are uncertain and may not be seen until after many years. Therefore, discuss the risks and benefits of treatment with clonazepam with your doctor.

Older adults may be more sensitive to the effects of this drug, especially drowsiness and confusion. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

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Clonazepam Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: orlistatsodium oxybate.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolamlorazepam, zolpidem), muscle relaxants (such as carisoprodolcyclobenzaprine), or antihistamines (such as cetirizinediphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

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How should I take clonazepam?

Take clonazepam exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Clonazepam may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Clonazepam should be used for only a short time. Do not take this medication for longer than 9 weeks without your doctor’s advice.

Swallow the tablet whole, with a full glass of water.

If you use this medicine long-term, you may need frequent medical tests.

Do not stop using clonazepam suddenly or you could have unpleasant withdrawal symptoms, including a seizure (convulsions). Ask your doctor how to safely stop using this medicine.

Call your doctor if this medicine seems to stop working as well in treating your seizures or anxiety symptoms.

Seizures are often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor’s advice.

Store clonazepam at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Clonazepam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, fainting, or coma.

What should I avoid while taking clonazepam?

Avoid drinking alcohol. Dangerous side effects could occur. Avoid taking similar medications, such as lorazepam (Ativan) or diazepam (Valium) as well as narcotics.

Clonazepam may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Forms and strengths

Generic: Clonazepam

  • Form: oral tablet
  • Strengths: 0.5 mg, 1 mg, 2 mg
  • Form: oral disintegrating tablet
  • Strengths: 0.125 mg, 0.25, 0.5 mg, 1 mg, 2 mg

Brand: Klonopin

  • Form: oral tablet
  • Strengths: 0.5 mg, 1 mg, 2 mg

Dosage for panic disorder

Adult dosage (ages 18 to 64 years)

  • Typical starting dose: 0.25 mg taken twice per day
  • Dose increases: A doctor may increase the dose to 0.5 mg taken two times per day after three days.
  • Maximum dose: 4 mg per day.
  • Dose reduction: A doctor should decrease a person’s dose slowly when stopping treatment with this drug. They should decrease the dose by no more than 0.125 mg every three days. For example, if the person was taking 2 mg two times per day, their doctor would start by decreasing the dose to 1.875 mg, taken two times per day.

Child dosage (ages 0 to 17 years)

It hasn’t been confirmed that clonazepam is safe and effective for use in people younger than 18 years for this condition.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause their body to process drugs more slowly. As a result, more of a drug stays in their body for a longer time. This raises their risk of side effects. Their doctor may start them on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in their body.

Dosage for seizures

Adult dosage (ages 18 to 64 years)

  • Typical starting dose: 0.5 mg taken three times per day
  • Dose increases: A doctor may increase a person’s dose by 0.5 to 1 mg every three days until their seizures are controlled.
  • Maximum dose: 20 mg per day, taken in divided doses.

Child dosage (ages 11 to 17 years)

  • Typical starting dose: 0.5 mg taken three times per day
  • Dose increases: A doctor may increase a child’s dose by 0.5 to 1 mg every three days until their seizures are controlled.
  • Maximum dose: 20 mg per day, taken in divided doses.

Child dosage (ages 0 to 10 years or children who weigh 66 lbs. [30 kg] or less)

  • Typical starting dose: 0.01 to 0.03 mg/kg of body weight per day. The dose shouldn’t be more than 0.05 mg/kg per day given in two to three divided doses.
  • Dose increases: A doctor may increase a child’s dose by 0.25 to 0.5 mg every three days until their seizures are controlled.
  • Maximum dose: 0.1–0.2 mg/kg per day taken in divided doses.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause their body to process drugs more slowly. As a result, more of a drug stays in their body for a longer time. This raises their risk of side effects. Their doctor may start them on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in their body.

Take as directed

Clonazepam oral tablet is used for short-term treatment. It comes with risks if a person does not take it as prescribed.

If a person stops taking the drug suddenly or doesn’t take it at all: If a person does not take this drug, their panic disorder or seizures won’t get better and may get worse. If they stop taking it suddenly, they may have symptoms of withdrawal. These include irritability, trouble sleeping, and anxiety.

If a person misses doses or doesn’t take the drug on schedule: They may have withdrawal symptoms if they don’t take the drug on schedule.

If a person takes too much: They could have dangerous levels of the drug in their body. Symptoms of an overdose of this drug can include:

  • sleepiness or drowsiness
  • confusion
  • trouble with coordination or slow reflexes
  • coma (being unconscious for a long time)

If a person thinks they have taken too much of this drug, they should call their doctor or local poison control center. If their symptoms are severe, they should call 911 or go to the nearest emergency room right away.

What to do if a person misses a dose: A person usually should take a missed dose as soon as they remember. But if they remember just a few hours before their next scheduled dose, take only one dose. They should never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: A person should have fewer panic attacks or seizures.

Klonopin is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, Klonopin may be useful.
SIDE EFFECTS
The adverse experiences for Klonopin are provided separately for patients with seizure disorders and panic disorder.
Seizure Disorders
        The most frequently occurring side effects of Klonopin are referable to CNS depression. Experience in treatment of seizures has shown that drowsiness has occurred in approximately 50% of patients and ataxia in approximately 30%. In some cases, these may diminish with time; behaviour problems have been noted in approximately 25% of patients. Others, listed by system, including those identified during postapproval use of Klonopin are:
• Cardiovascular: Palpitations
• Dermatologic: Hair loss, hirsutism, skin rash, ankle and facial oedema
• Gastrointestinal: Anorexia, coated tongue, constipation, diarrhoea, dry mouth, encopresis, gastritis, increased appetite, nausea, sore gums
• Genitourinary: Dysuria, enuresis, nocturia, urinary retention
• Hematopoietic: Anemia, leukopenia, thrombocytopenia, eosinophilia
• Hepatic: Hepatomegaly, transient elevations of serum transaminases and alkaline phosphatase
• Musculoskeletal: Muscle weakness, pains
• Miscellaneous: Dehydration, general deterioration, fever, lymphadenopathy, weight loss or gain
• Neurologic: Abnormal eye movements, aphonia, choreiform movements, coma, diplopia dysarthria, dysdiadochokinesis, ‘‘glassy-eyed’’ appearance, headache, hemiparesis, hypotonia, nystagmus, respiratory depression, slurred speech, tremor, vertigo
• Psychiatric: Confusion, depression, amnesia, hysteria, increased libido, insomnia, psychosis (the behaviour effects are more likely to occur in patients with a history of psychiatric disturbances).
• The following paradoxical reactions have been observed: irritability, aggression, agitation, nervousness, hostility, anxiety, sleep disturbances, nightmares, abnormal dreams, hallucinations.
• Respiratory: Chest congestion, rhinorrhea, shortness of breath, hypersecretion in upper respiratory passages
Panic Disorder
        Adverse events during exposure to Klonopin were obtained by spontaneous report and recorded by clinical investigators using the terminology of their own choosing. Consequently, it is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse events without first grouping similar types of events into a smaller number of standardized event categories. In the tables and tabulations that follow, CIGY dictionary terminology has been used to classify reported adverse events, except in certain cases in which redundant terms were collapsed into more meaningful terms, as noted below.
        The stated frequencies of adverse events represent the proportion of individuals who experienced, at least once, a treatment-emergent adverse event of the type listed. An event was considered treatment-emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation.
• Adverse Findings Observed In Short-Term, Placebo-Controlled Trials
• Adverse Events Associated With Discontinuation Of Treatment
• Overall, the incidence of discontinuation due to adverse events was 17% in Klonopin compared to 9% for placebo in the combined data of two 6- to 9-week trials.
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