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Xenical is a prescription medicine used to treat the symptoms of obesity management in the presence of other risk factors or diseases such as high blood pressure, diabetes mellitus or hyperlipidemia.(Buy xenical online)

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Description

What is Xenical and how is it used? (Buy xenical online)

Xenical is a prescription medicine used to treat the symptoms of obesity management in the presence of other risk factors or diseases such as high blood pressure, diabetes mellitus or hyperlipidemia. Xenical may be used alone or with other medications.

Xenical is a gastrointestinal agent.

It is not known if Xenical is safe and effective in children younger than 12 years of age.

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What are the possible side effects of Xenical?(Buy xenical online)

  • severe stomach pain,
  • severe pain in your lower back,
  • blood in your urine,
  • painful or difficult urination,
  • little or no urination,
  • swelling in your feet or ankles,
  • feeling tired,
  • shortness of breath,
  • nausea,
  • upper stomach pain,
  • itching,
  • loss of appetite,
  • dark colored urine,
  • clay-colored stools, and
  • yellowing of the skin or eyes (jaundice)

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Xenical include:

  • oily or fatty stools,
  • oily spotting in your undergarments,
  • orange or brown colored oil in your stool,
  • gas or oily discharge,
  • loose stools,
  • urgent need to go to the bathroom,
  • inability to control bowel movements,
  • increased number of bowel movements,
  • stomach pain,
  • nausea, and
  • rectal pain

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Xenical. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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DESCRIPTION

XENICAL (orlistat) is a gastrointestinal lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats.

Orlistat is (S)-2-formylamino-4-methyl-pentanoic acid (S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2-oxetanyl] methyl]-dodecyl ester. Its empirical formula is C29H53NO5, and its molecular weight is 495.7. It is a single diastereomeric molecule that contains four chiral centers, with a negative optical rotation in ethanol at 529 nm. The structure is:

XENICAL (orlistat) Structural Formula Illustration

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Orlistat is a white to off-white crystalline powder. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Orlistat has no pK within the physiological pH range.

XENICAL is available for oral administration as a turquoise hard-gelatin capsule. The capsule is imprinted with black. Each capsule contains a pellet formulation consisting of 120 mg of the active ingredient, orlistat, as well as the inactive ingredients microcrystalline cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone, and talc. The capsule shell contains gelatin, titanium dioxide, and FD&C Blue No. 2 with black printing ink containing pharmaceutical grade shellac, propylene glycol, strong ammonium solution, potassium hydroxide and black iron oxide.

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Side Effects

Changes in your bowel function often occur because of the unabsorbed fat. Fatty/oily stool, oily spotting, intestinal gas with discharge, a feeling of needing to have a bowel movement right away, increased number of bowel movements, or poor bowel control may occur. These side effects may get worse if you eat more fat than you should. If these effects persist or worsen, notify your doctor promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Stop taking this medication and tell your doctor right away if any of these rare but serious side effects occur: symptoms of liver disease (such as persistent nausea/vomiting, severe stomach/abdominal paindark urine, yellowing eyes/skin), symptoms of kidney stones (such as back pain, pain when urinating, pink/bloody urine).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rashitching/swelling (especially of the face/tongue/throat), severe dizzinesstrouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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INDICATIONS

XENICAL is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. XENICAL is also indicated to reduce the risk for weight regain after prior weight loss. XENICAL is indicated for obese patients with an initial body mass index (BMI) ≥ 30 kg/m² or ≥ 27 kg/m² in the presence of other risk factors (e.g., hypertensiondiabetesdyslipidemia).

Table 1 illustrates body mass index (BMI) according to a variety of weights and heights. The BMI is calculated by dividing weight in kilograms by height in meters squared. For example, a person who weighs 180 lbs and is 5-5” would have a BMI of 30.

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Table 1 Body Mass Index (BMI), kg/m²*

WEIGHT (lb)
120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320
Height (ft/in) 4’10” 25 27 29 31 34 36 38 40 42 44 46 48 50 52 54 57 59 61 63 65 67
4’11” 24 26 28 30 32 34 36 38 40 43 45 47 49 51 53 55 57 59 61 63 65
5’0” 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59 61 63
5’1” 23 25 27 28 30 32 34 36 38 40 42 44 45 47 49 51 53 55 57 59 61
5’2” 22 24 26 27 29 31 33 35 37 38 40 42 44 46 48 49 51 53 55 57 59
5’3” 21 23 25 27 28 30 32 34 36 37 39 41 43 44 46 48 50 51 53 55 57
5’4” 21 22 24 26 28 29 31 33 34 36 38 40 41 43 45 46 48 50 52 53 55
5’5” 20 22 23 25 27 28 30 32 33 35 37 38 40 42 43 45 47 48 50 52 53
5’6” 19 21 23 24 26 27 29 31 32 34 36 37 39 40 42 44 45 47 49 50 52
5’7” 19 20 22 24 25 27 28 30 31 33 35 36 38 39 41 42 44 46 47 49 50
5’8” 18 20 21 23 24 26 27 29 30 32 34 35 37 38 40 41 43 44 46 47 49
5’9” 18 19 21 22 24 25 27 28 30 31 33 34 36 37 38 40 41 43 44 46 47
5’10” 17 19 20 22 23 24 26 27 29 30 32 33 35 36 37 39 40 42 43 45 46
5’11” 17 18 20 21 22 24 25 27 28 29 31 32 34 35 36 38 39 41 42 43 45
6’0” 16 18 19 20 22 23 24 26 27 29 30 31 33 34 35 37 38 39 41 42 43
6’1” 16 17 19 20 21 22 24 25 26 28 29 30 32 33 34 36 37 38 40 41 42
6’2” 15 17 18 19 21 22 23 24 26 27 28 30 31 32 33 35 36 37 39 40 41
*Conversion Factors:
Weight in lbs · 2.2 = weight in kilograms (kg)
Height in inches — 0.0254 = height in meters (m)

Precautions

Before taking orlistat, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain digestive problem (chronic malabsorption syndrome), a certain gall bladder problem (cholestasis), underactive thyroid (hypothyroidism), kidney stones/problems (such as calcium oxalate kidney stones, hyperoxaluria), certain eating disorders (anorexia nervosa/bulimia), HIV infection, seizures.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you are diabetic, weight loss may improve your blood sugar control. Be sure to check your blood sugar regularly and tell your doctor the results. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication must not be used during pregnancyWeight loss offers no potential benefit to a pregnant woman and may harm an unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

DOSAGE AND ADMINISTRATION

Recommended Dosing

The recommended dose of XENICAL is one 120-mg capsule three times a day with each main meal containing fat (during or up to 1 hour after the meal).

The patient should be on a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. The daily intake of fat, carbohydrate, and protein should be distributed over three main meals. If a meal is occasionally missed or contains no fat, the dose of XENICAL can be omitted.

Because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and betacarotene, patients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition [see WARNINGS AND PRECAUTIONS]. The vitamin supplement should be taken at least 2 hours before or after the administration of XENICAL, such as at bedtime.

For patients receiving both XENICAL and cyclosporine therapy, administer cyclosporine 3 hours after XENICAL.

For patients receiving both XENICAL and levothyroxine therapy, administer levothyroxine and XENICAL at least 4 hours apart. Patients treated concomitantly with XENICAL and levothyroxine should be monitored for changes in thyroid function.

Doses above 120 mg three times a day have not been shown to provide additional benefit.

Based on fecal fat measurements, the effect of XENICAL is seen as soon as 24 to 48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48 to 72 hours.

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Xenical is a weight-loss medication mostly prescribed to treat morbid obesity. The chemical name of the medicine is Orlistat. The active ingredient is Orlistat. This can be bought over the counter as Alli. Each capsule would contain 120mg of Orlistat. By taking this medication, the enzymes would not be broken down and thus, would make the fat, indigestible and would be removed through bowel movement.

Doctors recommend people who are very obese to buy Xenical online. This is because this drug help them reduce the risk of any medical condition related to obesity like heart attack, diabetes, high blood pressure and many others. Also patients should be able to find a considerable change in weight, within 2 weeks of using this drug. Therefore if your weight remains the same or increases, make sure you consult a doctor

Dosage Recommendation for Xenical

Xenical is available in dosage strength of 120 mg. Adults who are obese should take Xenical 120 mg three times during the course of the day.

Therefore to the maximum the result, this drug should be taken along with the meal or after an hour upon finishing your meal. Also the same dosage recommendation is applicable for pediatrics patients as well.

Xenical has the potential to contain the absorption fat-soluble vitamins. Hence, patients undergoing course of therapy with the medications should be instructed to ensure adequate intake of vitamins and other essential nutrients. At instance of administering any vitamin supplement, it should only be two hours before or after taking this drug. Thus patients are advised to take any vitamin/nutrient supplement at bedtime.

Side effects of Xenical

Side effects are common with this medicine. The severe side effects are,

  • intestinal gas with discharge,
  • oily spotting,
  • oily stool.

Also allergic reaction to this medicine is very rare and the symptoms of allergic reactions are

  • severe dizziness,
  • troubled breathing,
  • swelling,
  • itching and rash.

Therefore if a patient experience allergic reactions or the severe side effects, he/she should stop the medicine and contact the doctor immediately.

Contact the doctor immediately if you experience symptoms like,

  • dark urine,
  • yellowing of the skin,
  • stomach ache,
  • vomiting,
  • painful urination,
  • bloody or pink urine.

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