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Demerol is a prescription medicine used to treat the symptoms of moderate to severe pain. Demerol may be used alone or with other medications. Demerol belongs to a class of drugs called Synthetic, Opioids, Opioid Analgesics.

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WHAT IS DEMEROL (MEPERIDINE)?

Demerol 100 mg Sanofi Aventis is the brand name of the prescription drug meperidine.

The drug is used to treat moderate-to-severe pain, help put people to sleep before an operation, and provide pain relief after childbirth.

Demerol is classified as a Schedule II (C-II) controlled substance.

Demerol belongs to a class of pain medications called opioid analgesics, which work by binding to receptors on the surface of cells where opium normally binds, and stopping the body from sending pain signals to the brain.

Originally manufactured by Sanofi Aventis, the Food and Drug Administration (FDA) first approved Demerol in 1942.

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DEMEROL 100 MG SANOFI AVENTIS WARNINGS

You shouldn’t take Demerol 100 mg Sanofi Aventis if you are allergic to meperidine or any of the drug’s inactive ingredients.

Before taking Demerol, you should tell your doctor if you:

  • Are 65 or older, or have been taking Demerol 100 mg Sanofi Aventis for a long period of time
  • Have used a monoamine oxidase inhibitor (MAOI) — such as Nardil (phenelzine), Emsam or Eldepryl (selegiline), and Parnate (tranylcypromine) — within the last 14 days
  • Have decreased or insufficient breathing (respiratory depression)

Ask your doctor about Demerol if you have or have ever had:

  • Kidney or liver problems
  • Lung or breathing problems, including asthma or COPD
  • Obstructive sleep apnea
  • Underactive thyroid or underactive adrenal gland
  • Seizures
  • Stomach problems
  • Recent head injury, including a blow to the head or increased pressure inside the skin
  • An addiction to alcohol or drugs
  • An enlarged prostate, also known as benign prostatic hypertrophy (BPH)

DEMEROL SIDE EFFECTS

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COMMON SIDE EFFECTS OF DEMEROL

You should tell your doctor if any of the following side effects are severe or don’t go away:

  • Dizziness, headache, lightheadedness, sleepiness, and weakness
  • Nausea, vomiting, and constipation
  • Dry mouth
  • Sweating or flushing
  • Sudden drop in blood pressure upon standing, or slow heartbeat
  • Irritability, nervousness, and unusual thoughts
  • Shaking or controllable movement
  • Changes in vision
  • Itching, rash, or hives

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SERIOUS SIDE EFFECTS OF DEMEROL

You should stop using this medicine and call your doctor if you experience any of the following serious side effects:

  • Trouble breathing, shallow breathing, or stopping breathing
  • Very low blood pressure, slow heartbeat, and shock
  • Fainting
  • Hallucinations
  • Seizures

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DEMEROL INTERACTIONS

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You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking, especially:

  • Liposomal morphine
  • MAOIs such as Nardil (phenelzine), Matulane (procarbazine), Parnate (tranylcypromine), and Marplan (isocarboxazid)
  • Parkinson’s drugs like rasagiline, Eldepryl or Zelapar (selegiline), or Emsam (selegiline transdermal)

Other drugs that have serious interactions with Demerol 100 mg Sanofi Aventis include:

  • Zyvox (linezolid)
  • K-Phos (potassium chloride)
  • Talwin (pentazocine)
  • Potassium citrate
  • Drugs that contain ritonavir like Kaletra, Norvir, or Veikira Pak
  • Karbinal ER (carbinoxamine)

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DEMEROL 100 MG SANOFI AVENTIS AND ALCOHOL

Both Demerol and alcohol can cause dizziness, nausea, vomiting, and blurry vision.

Drinking while taking Demerol can make these side effects worse, so try to avoid, or at least limit, alcohol while taking Demerol.

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DEMEROL AND GRAPEFRUIT JUICE

You should avoid eating grapefruit and drinking grapefruit juice while taking Demerol.

Grapefruit juice slows down how quickly the body is able to break down the Demerol, which could cause Demerol levels in the blood to rise dangerously high.

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DEMEROL DOSAGE

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Demerol 50 mg Sanofi Aventis comes in 50 milligram (mg) and 100 mg tablets, while the injectable liquid comes in vials that contain 25 mg, 50 mg, 75 mg, or 100 mg per milliliter of solution.

If you’ve never taken Demerol or any other drug belonging to the opioid family, your doctor may start you at a lower dose of 50 mg, every 3 to 4 hours as needed for pain.

A typical dose ranges between 50 mg to 150 mg, every 3 to 4 hours on an as-needed basis.

It’s important to only take Demerol if you absolutely need it. This will prevent building tolerance or overdosing on the drug.

Demerol is not intended for long-term pain management, and unless directed by your doctor, you should not take more than 600 mg within a 24-hour period.

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DEMEROL OVERDOSE

If you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

MISSED DOSE OF DEMEROL

Because you should only take Demerol on an as-needed basis, you should not have to worry about missing a dose.

Never take extra doses to make up for a dose you didn’t take.

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Uses

Meperidine is used to help relieve moderate to severe pain. It belongs to a class of drugs known as opioid analgesics and is similar to morphine. It works in the brain to change how your body feels and responds to pain.Meperidine should not be used to treat long-term or ongoing pain. It should only be used to treat sudden episodes of moderate to severe pain. See also Precautions section.

How to use Demerol

Read the Medication Guide provided by your pharmacist before you start taking meperidine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually every 3 to 4 hours as needed. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Make sure not to confuse the dose of meperidine liquid in milligrams (mg) with the dose in milliliters (mL). Ask your pharmacist or doctor to show you the right way to measure your dose. Mix your dose with one-half glass of water (4 ounces/120 milliliters) and drink right away. Mixing your dose in water before you take it will prevent your mouth from becoming numb.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed because your risk of side effects may increase. Properly stop the medication when so directed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Suddenly stopping this medication may cause withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as restlessness, mental/mood changes (including anxietytrouble sleeping, thoughts of suicide), watering eyesrunny nose, nausea, diarrheasweating, muscle aches, or sudden changes in behavior.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your pain does not get better or if it gets worse.

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Side Effects

Nauseavomitingconstipationsweatinglightheadednessdizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

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Tell your doctor right away if you have any serious side effects, including: interrupted breathing during sleep (sleep apnea), mental/mood changes (such as agitation, confusion, hallucinations), stomach/abdominal pain, difficulty urinating, slow/irregular/fast heartbeat, shaking (tremors), vision changes, signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss).

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Get medical help right away if you have any very serious side effects, including: faintingseizure, severe drowsiness/difficulty waking up.

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrheatwitching muscles, unexplained fever, unusual agitation/restlessness.

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A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rashitching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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Precautions

Before taking meperidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

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Before taking this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthmasleep apneachronic obstructive pulmonary diseaseCOPD), gallbladder disease, kidney diseaseliver disease, mental/mood disorders (such as confusion, depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipationdiarrhea due to infection, paralytic ileus), disease of the pancreas (pancreatitis), difficulty urinating (such as due to enlarged prostate), pheochromocytomaheart problems (such as fast/irregular heartbeat), sickle cell anemia.

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Meperidine is usually used only for a short time. Repeated or high doses may cause drug levels to build up in the body and cause serious side effects such as seizures and shaking. Caution is advised if this medication is used for conditions that require long-term or high-dosage treatment (such as sickle cell anemia, burns, cancer). Consult your doctor or pharmacist for details.

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This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, drowsiness, and slow/shallow breathing.

Children may be more sensitive to the side effects of this drug, especially severe drowsiness and slow/shallow breathing.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor. (See also Warning section.)

This drug passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding.

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Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

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Some products that may interact with this drug include: certain pain medications (mixed opioid agonist-antagonists such as pentazocine, nalbuphine, butorphanol), naltrexone.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazidlinezolid, methylene blue, moclobemide, phenelzineprocarbazinerasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is used with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolamlorazepam, zolpidem), muscle relaxants (such as carisoprodolcyclobenzaprine), or antihistamines (such as cetirizinediphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

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The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Other medications can affect the removal of meperidine from your body, which may affect how meperidine works. Examples include azole antifungals (such as ketoconazole), macrolide antibiotics (such as erythromycin), mifepristone, rifamycins (such as rifabutin), ritonavir, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This medication may interfere with certain laboratory tests (including amylase/lipase tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, give them naloxone if available, then call 911. If the person is awake and has no symptoms, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow/shallow breathing, severe drowsiness, coma.

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Notes
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Do not share this medication with others. Sharing it is against the law.

This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case.

Ask your doctor or pharmacist if you should have naloxone available to treat opioid overdose. Teach your family or household members about the signs of an opioid overdose and how to treat it.

Missed Dose

Not applicable.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. For more details, read the Medication Guide, or consult your pharmacist or local waste disposal company.

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Images

Demerol 100 mg tablet

Demerol 100 mg tablet

Color: white

Shape: round

Imprint: logo D 37

This medicine is a white, round, tablet imprinted with “logo” and “D 37”.

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