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Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam (Valium).

Category:
Description

Bromazepam uses:

This medication is used to relieve anxiety, nervousness and tension.

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How to use Bromazepam

Take this medication by mouth exactly as directed by your doctor. Do not increase your dose, use it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. If used for an extended period, do not suddenly stop using this drug without your doctor’s approval. Over time, this drug may not work as well. Consult your doctor if this medication stops working well.

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Bromazepameffects:

Drowsiness, dizziness, or loss of coordination may occur. Dry mouthheadache or stomach upset rarely occurs. If any of these effects persist or worsen, inform your doctor. Notify your doctor if you develop: rapid/pounding or irregular heartbeat, changes in vision, slurred speech, confusiondepression, behavior changes. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rashitching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: kidney diseaseliver disease, muscle problems (myasthenia gravis), history of chemical or alcohol dependencedepression, any allergies you may have. Limit alcohol intake because it may increase the drowsiness and dizziness caused by this medication. Because this medication may make you drowsy/dizzy, use caution performing task requiring alertness such as driving or using machinery. The elderly may be more sensitive to the effects of this medication. Use cautiously. This medication is not recommended for use during pregnancy. Consult your doctor before using this medication. Bromazepam may be excreted into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially of: anti- seizure medication, antidepressants, certain antihistamines (e.g., diphenhydramine), narcotic pain relievers, sleeping pills, tranquilizers. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include confusion, slow reflexes, clumsiness, deep sleep, and loss of consciousness.

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NOTES: Do not share this medication with others.

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MISSED DOSE: Try to take each dose at the scheduled time. If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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STORAGE: Store this medication at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from heat and light. Do not store in the bathroom. Keep this and all medications out of the reach of children.

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WHAT SIDE EFFECTS ARE POSSIBLE WITH THIS MEDICATION?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • clumsiness or unsteadiness
  • constipation
  • delayed reactions
  • dizziness or lightheadedness
  • drowsiness
  • headache
  • nausea
  • slurred speech

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • anxiety
  • behaviour changes (e.g., aggressiveness, agitation, unusual excitement, nervousness, or irritability)
  • confusion
  • fast, pounding, or irregular heartbeat
  • hallucinations (hearing or seeing things that aren’t there)
  • memory loss of recent events
  • nightmares or trouble sleeping
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • urinary problems (leakage, increased urgency to urinate)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

ARE THERE ANY OTHER PRECAUTIONS OR WARNINGS FOR THIS MEDICATION?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

October 30, 2020

Health Canada has issued new restrictions concerning the use of benzodiazepines and benzodiazepine-like prescription drugs. To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.

Alcohol: People taking this medication should not consume alcohol since doing so can reduce the effectiveness of this medication and increase the risk of side effects.

People who have an addiction to alcohol or other drugs should not take bromazepam except in rare situations under medical supervision.

Breathing: Bromazepam can suppress breathing. This effect on breathing may be more pronounced for people with breathing problems, brain damage, or who are taking other medications that suppress breathing (e.g., codeine, morphine). If you have severe breathing problems, discuss the risks and benefits of taking this medication your doctor.

Dependence and withdrawal: Physical dependence (a need to take regular doses to prevent physical symptoms) has been associated with benzodiazepines such as bromazepam. Severe withdrawal symptoms may be experienced (e.g., seizures) if the dose is significantly reduced or bromazepam is suddenly stopped. Withdrawal symptoms include irritability, nervousness, sleep problems, agitation, tremors, diarrhea, abdominal cramps, vomiting, memory impairment, headache, muscle pain, extreme anxiety, tension, restlessness, and confusion. Reducing the dose gradually under medical supervision can help prevent or decrease these withdrawal symptoms.

Depression: Bromazepam, like other benzodiazepines, has been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking this medication, contact your doctor as soon as possible.

Bromazepam is not recommended for use by people with depression or psychosis or who have attempted suicide.

Drowsiness/reduced alertness: Bromazepam causes drowsiness and sedation. Avoid activities requiring mental alertness, judgment, or physical coordination (such as driving or operating machinery) while taking it. This is particularly true when first taking the medication and until you have established how bromazepam affects. Alcohol may increase the drowsiness effects and should be avoided.

Lactose intolerance: Lactose is one of the ingredients in this medication. If you have a hereditary condition that makes you intolerant to lactose, discuss other alternatives with your doctor.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you take bromazepam and suspect you are pregnant or plan to become pregnant, consult your doctor before stopping bromazepam suddenly.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are taking bromazepam, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Bromazepam is not recommended for use by children or adolescents under 18 years of age.

Seniors: Seniors may be at increased risk of experiencing the sedative and impaired coordination effects of bromazepam. They need to exercise extra caution, for example, to avoid falling when getting up during the night.

WHAT OTHER DRUGS COULD INTERACT WITH THIS MEDICATION?

There may be an interaction between bromazepam and any of the following:

  • alcohol
  • antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • aprepitant
  • aripiprazole
  • “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • baclofen
  • barbiturates (e.g., butalbital, phenobarbital)
  • benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
  • buspirone
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • carbamazepine
  • chloral hydrate
  • cimetidine
  • deferasirox
  • efavirenz
  • ethinyl estradiol (birth control pills)
  • gabapentin
  • gemfibrozil
  • grapefruit juice
  • isoniazid
  • lamotrigine
  • levetiracetam
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • medroxyprogesterone
  • mexiletine
  • mirtazapine
  • muscle relaxants (e.g., cyclobenzaprine, methocarbamol, orphenadrine)
  • narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
  • olopatadine
  • phenytoin
  • primaquine
  • proton pump inhibitors (e.g., lansoprazole, omeprazole)
  • rifampin
  • rifabutin
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • scopolamine
  • St. Johns wort
  • tapentadol
  • theophylline
  • topiramate
  • tramadol
  • tranylcypromine
  • tricyclic antidepressasnts (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • vemurafenib
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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