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Amlodipine 10 mg is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years and older.

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Description

Uses of amlodipine 10 mg

Amlodipine 10 mg is used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily.Amlodipine is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.

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How to use Amlodipine 10 mg

Read the Patient Information Leaflet if available from your pharmacist before you start taking amlodipine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

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Take this medication by mouth with or without food as directed by your doctor, usually once daily.

Some brands of the liquid form of this medication should be shaken before use, while other brands should not be shaken before use. Check the manufacturer’s information or ask your pharmacist for specific directions. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

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The dosage is based on your medical condition and response to treatment. Your doctor may gradually increase your dose. Follow your doctor’s instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

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If used for angina, this medication must be taken regularly to be effective. It should not be used to treat angina when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details.

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Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase, chest pain continues or worsens).

Amlodipine 10 mgSide Effects

Dizzinesslightheadedness, swelling ankles/feet, or flushing may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

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Tell your doctor right away if any of these unlikely but serious side effects occur: fast/irregular/pounding heartbeat, fainting.

Although this medication is effective in preventing chest pain (angina), some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

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A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rashitching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

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This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Before taking amlodipine, tell your doctor or pharmacist if you are allergic to it; or to other dihydropyridine calcium channel blockers (such as nisoldipine, nifedipine) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

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Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain structural heart problem (aortic stenosis), very low blood pressureliver disease.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this drug, especially dizziness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products have ingredients that could raise your blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, severe dizziness.

Notes

Do not share this medication with others.

Lifestyle changes that may help this medication work better include exercising, stopping smoking, reducing stress, and eating a low-cholesterol/low-fat diet. Consult your doctor for more details.

Lab and/or medical tests (such as blood pressure) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure at home, and share the results with your doctor.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store the tablets at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Store the liquid form of this medication in the refrigerator away from light. Do not freeze.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Brand Name: Norvasc

Generic Name: amlodipine

Drug Class: Calcium Channel Blockers; Antianginal Agents

WHAT IS AMLODIPINE AND HOW DOES IT WORK?

Amlodipine a prescription medication that is used with or without other medications to treat high blood pressure. Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems. Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily.

Amlodipine is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.

Amlodipine is available under the following different brand names: Norvasc.

DOSAGES OF AMLODIPINE SHOULD BE GIVEN AS FOLLOWS:

Adult and Pediatric Dosage Forms & Strengths

Tablets

  • 2.5 mg
  • 5 mg
  • 10 mg

Dosage Considerations

Hypertension (High Blood Pressure)

Adult

  • 5 mg/day orally initially; may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day orally; maintenance: 5-10 mg/day orally

Pediatric

  • Children under 6 years: Safety and efficacy not established
  • Children 6 years and older: 2.5-5 mg/day orally

Geriatric

  • 2.5-5 mg/day orally initially; may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day orally; maintenance: 5-10 mg/day orally

Coronary Artery Disease

Treatment of chronic stable angina and vasospastic angina (Prinzmetal or variant angina) and angiographically documented coronary artery disease (CADin patients without heart failure or ejection fraction (EF) less than 40%

Adult

  • 5-10 mg/day orally initially; maintenance: 10 mg/day orally

Geriatric

  • 2.5-10 mg/day orally initially; maintenance: 10 mg/day orally

Angina

Adult

  • 5-10 mg/day orally; maintenance: 10 mg/day orally

Geriatric

  • 2.5-10 mg/day orally; maintenance: 10 mg/day

Dosage Modifications

Hepatic insufficiency: Consider starting with 2.5 mg/day orally

Severe hepatic impairment: Titrate slowly

Dosing Considerations

Also given in combination with benazepril (Lotrel), atorvastatin (Caduet), olmesartan (Azor), telmisartan (Twynsta), and valsartan (Exforge)

Geriatric

  • Start dosing at low end of dosing range; elderly patients have greater frequency of decreased renal, hepatic or cardiac function

WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING AMLODIPINE?

Side effects of amlodipine include:

Postmarketing side effects of amlodipine reported include:

  • Extrapyramidal disorder (muscle spasms, restlessness, muscle rigidity, slow movement, tremor, and jerky movements)

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

WHAT OTHER DRUGS INTERACT WITH AMLODIPINE?

 

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of amlodipine include:

  • dantrolene

Serious Interactions of amlodipine include:

Amlodipine moderate interactions with at leas 92 different drugs.

Amlodipine moderate interactions with at leas 100 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

WHAT ARE WARNINGS AND PRECAUTIONS FOR AMLODIPINE?

 

Warnings

This medication contains amlodipine. Do not take Norvasc if you are allergic to amlodipine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Hypersensitivity

Effects of Drug Abuse

None

Short-term Effects

See “What Are Side Effects Associated with Using Amlodipine?”

Long-term Effects

See “What Are Side Effects Associated with Using Amlodipine?”

Cautions

Congestive heart failure (CHF).

Persistent progressive dermatologic reactions.

Symptomatic hypotension with or without syncope possible, particularly with severe aortic stenosis; because of gradual onset of action, acute hypotension unlikely.

Worsening of angina and acute myocardial infarction (MI) can develop after dose is started or increased, particularly with severe obstructive CAD.

Peripheral edema may develop within 2-3 weeks of starting therapy.

Use with caution in patients with hypertrophic cardiomyopathy; reduction in afterload may worsen symptoms associated with this condition.

May reduce coronary perfusion and result in ischemia in patients with severe aortic stenosis; use caution.

Extensively metabolized by liver; titrate dose slowly with severe hepatic impairment.

Initiate at lower dose in the elderly.

Titrate dose every 7-14 days on a given dose; peak antihypertensive effect is delayed.

Co-administration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction; monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A inhibitors to determine the need for dose adjustment.

Amlodipine may increase systemic exposure of cyclosporine or tacrolimus when co-administered; frequent monitoring of trough blood levels of cyclosporine and tacrolimus recommended; adjust dose when appropriate

Pregnancy and Lactation

Use amlodipine with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

It is unknown whether amlodipine is excreted in milk; use of amlodipine while breastfeeding is not recommended.

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